XPO7 Gene Summary [Human]
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | XPO7 |
| Official Name | exportin 7 [Source:HGNC Symbol;Acc:HGNC:14108] |
| Ensembl ID | ENSG00000130227 |
| Bio databases IDs | |
| Aliases | exportin 7 |
| Synonyms | 4930506C02RIK, EXP7, exportin 7, RANBP16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XPO7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- protein binding
- Importin-beta N-terminal domain
- nuclear export signal receptor
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- Alzheimer disease
- cancer
- liver neoplasia
- epithelial neoplasia
- epithelial cancer
- liver cancer
- organismal death
- atrial fibrillation
- digestive system cancer
role in cell
- expression in
- senescence
- quantity
- condensation in
- density
- size
- oncogene-induced senescence
- replicative senescence
- condensation
- enucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear pores
- nuclear envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XPO7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- nuclear export signal receptor activity