HABP4 Gene Summary [Human]
Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HABP4 |
| Official Name | hyaluronan binding protein 4 [Source:HGNC Symbol;Acc:HGNC:17062] |
| Ensembl ID | ENSG00000130956 |
| Bio databases IDs | |
| Aliases | hyaluronan binding protein 4 |
| Synonyms | 4933413D03Rik, 4933428J01Rik, hyaluronan binding protein 4, hyaluronic acid binding protein 4, IHABP-4, Ki-1/57, SERBP1L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HABP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hyaluronan / mRNA binding family
- ribosome binding
- protein binding
- hyaluronic acid binding
- Intracellular hyaluronan-binding protein 4 N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- sarcomere
- cytosol
- nucleoli
- nuclear bodies
- nuclear envelope
- nuclear speckles
- Cajal bodies
- synapse
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HABP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- cellular response to mechanical stimulus
- negative regulation of DNA binding
- RNA splicing
- positive regulation of RNA splicing
- mRNA processing
- PML body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasmic stress granule
- sarcoplasm
- cytoplasm
- nuclear speck
- Cajal body
- cytosol
- extracellular region
- nucleolus
- sarcomere
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- RNA binding
- protein binding
- ribosome binding