Habp4 Gene Summary [Mouse]
Predicted to enable several functions, including SUMO binding activity; hyaluronic acid binding activity; and translation elongation factor binding activity. Predicted to be involved in PML body organization; cellular response to mechanical stimulus; and regulation of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is active in synapse. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Habp4 |
| Official Name | hyaluronic acid binding protein 4 [Source:MGI Symbol;Acc:MGI:1891713] |
| Ensembl ID | ENSMUSG00000021476 |
| Bio databases IDs | |
| Aliases | hyaluronic acid binding protein 4 |
| Synonyms | 4933413D03Rik, 4933428J01Rik, hyaluronan binding protein 4, hyaluronic acid binding protein 4, IHABP-4, Ki-1/57, SERBP1L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Habp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hyaluronan / mRNA binding family
- ribosome binding
- protein binding
- hyaluronic acid binding
- Intracellular hyaluronan-binding protein 4 N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- sarcomere
- cytosol
- nucleoli
- nuclear bodies
- nuclear envelope
- nuclear speckles
- Cajal bodies
- synapse
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Habp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- cellular response to mechanical stimulus
- negative regulation of DNA binding
- RNA splicing
- positive regulation of RNA splicing
- mRNA processing
- PML body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasmic stress granule
- sarcoplasm
- cytoplasm
- nuclear speck
- Cajal body
- cytosol
- extracellular region
- nucleolus
- sarcomere
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- RNA binding
- protein binding
- ribosome binding