ULBP1 Gene Summary [Human]
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | ULBP1 |
| Official Name | UL16 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:14893] |
| Ensembl ID | ENSG00000111981 |
| Bio databases IDs | |
| Aliases | UL16 binding protein 1 |
| Synonyms | A430108B07RIK, AC147512.2, ALCAN-beta, ALCAN-β, LOC120100095, MULT1, N2DL1, NKG2DL1, RAET1I, UL16 binding protein 1, uncharacterized LOC120100095 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- receptor agonist activity
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ULBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- expression in
- proliferation
- activation
- binding
- cytotoxicity
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- membrane rafts
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- signal transduction
- natural killer cell activation
- natural killer cell mediated cytotoxicity
- positive regulation of T cell mediated cytotoxicity
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor agonist activity
- natural killer cell lectin-like receptor binding