CAP1 Gene Summary [Human]
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | CAP1 |
| Official Name | cyclase associated actin cytoskeleton regulatory protein 1 [Source:HGNC Symbol;Acc:HGNC:20040] |
| Ensembl ID | ENSG00000131236 |
| Bio databases IDs | |
| Aliases | cyclase associated actin cytoskeleton regulatory protein 1 |
| Synonyms | Adenylyl cyclase-associated, CAP, CAP1-PEN, Cap adenylate cyclase associated protein 1, cyclase associated actin cytoskeleton regulatory protein 1, Mch1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenylate cyclase associated (CAP) N terminal
- Adenylate cyclase associated (CAP) C terminal
- central domain
- Tubulin binding cofactor C
- protein binding
Pathways
Biological processes and signaling networks where the CAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant Emery-Dreifuss muscular dystrophy
- essential thrombocythemia
- juvenile dermatomyositis
- colorectal cancer
- early onset hypertension
- neonatal late-onset sepsis
- Duchenne muscular dystrophy
- postmenopausal osteoporosis
role in cell
- growth
- activation in
- growth in
- migration
- phosphorylation in
- development
- morphogenesis
- depolymerization
- organization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- glutaminergic synapse
- cortical actin cytoskeleton
- azurophil granule lumen
- Cytoplasm
- presynaptic regions
- Extracellular Space
- postsynaptic region
- actin cytoskeleton
- cytosol
- membrane ruffles
- growth cone
- actin stress fibers
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ameboidal cell migration
- signal transduction
- cell morphogenesis
- establishment or maintenance of cell polarity
- actin filament organization
- activation of adenylate cyclase activity
- receptor-mediated endocytosis
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- extracellular region
- azurophil granule lumen
- cortical actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- adenylate cyclase binding