RPS6KA3 Gene Summary [Human]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KA3 |
| Official Name | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] |
| Ensembl ID | ENSG00000177189 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase A3 |
| Synonyms | C130006E23, CLS, HU-3, ISPK-1, MAPKAPK-1b, MAPKAP Kinase 1 Beta, MAPKAP Kinase 1 β, MPK-9, MRX19, p90-RSK2, p90RSK3, pp90RSK2, RGD1563860, ribosomal protein S6 kinase A3, ribosomal protein S6 kinase polypeptide 3, RSK, RSK2, S6K-alpha3, XLID19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- ERK-binding site
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- caspase inhibitor activity
- PIF binding pocket
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- PDZ binding motif
- Tyrosine kinase, catalytic domain
- hydrophobic domain
Pathways
Biological processes and signaling networks where the RPS6KA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- NGF Signaling
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- p38 MAPK Signaling
- Phospholipase C Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- UVA-Induced MAPK Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ST-elevation myocardial infarction
- metastasis
- epithelial cancer
- cancer
- neoplasia
- osteopenia
- prostate cancer
- x-linked mental retardation type 19
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- growth
- phosphorylation in
- expression in
- accumulation in
- apoptosis
- activation in
- quantity
- invasion by
- phagocytosis
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- Plasma Membrane
- actin filaments
- cytosol
- synaptic membrane
- nucleoplasm
- nucleoli
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- synaptic transmission
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of translation in response to stress
- toll-like receptor signaling pathway
- positive regulation of cell growth
- central nervous system development
- skeletal system development
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- response to lipopolysaccharide
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- synapse
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ribosomal protein S6 kinase activity
- protein kinase binding
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process