TRAPPC10 Gene Summary [Human]
The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRAPPC10 |
| Official Name | trafficking protein particle complex 10 [Source:HGNC Symbol;Acc:HGNC:11868] |
| Ensembl ID | ENSG00000160218 |
| Bio databases IDs | |
| Aliases | trafficking protein particle complex 10, trafficking protein particle complex subunit 10, trafficking protein particle complex subunit 130, TRAPP 130 kDa subunit |
| Synonyms | B230307C21, B230307C21Rik, b2b2416Clo, b2b2613Clo, EHOC-1, Gm870, GT334, LOC100504963, NEDMISS, TMEM1, trafficking protein particle complex 10, trafficking protein particle complex subunit 10, TRS130, TRS30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAPPC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trafficking protein particle complex subunit 10, TRAPPC10
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- inflammatory bowel disease
- Down syndrome
- neurodevelopmental disorder with microcephaly, short stature, and speech delay
- mental retardation
- Crohn disease
- neurodevelopmental disorder with microcephaly, short stature, speech delay, and behavioral abnormalities
regulated by
- Dengue virus 2 Thailand/NGS-C/1944
- Influenza A virus (A/Bangkok/RX73(H3N2))
role in cell
- vesicle transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAPPC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle coating
- ER to Golgi vesicle-mediated transport
- intra-Golgi vesicle-mediated transport
- early endosome to Golgi transport
Cellular Component
Where in the cell the gene product is active
- TRAPP complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding