Bcan Gene Summary [Rat]
Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in cell-matrix adhesion; neurogenesis; and regulation of neuronal synaptic plasticity. Located in several cellular components, including main axon; perineuronal net; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Used to study high grade glioma. Biomarker of high grade glioma and middle cerebral artery infarction. Orthologous to human BCAN (brevican). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcan |
| Official Name | brevican [Source:RGD Symbol;Acc:2194] |
| Ensembl ID | ENSRNOG00000018798 |
| Bio databases IDs | |
| Aliases | brevican |
| Synonyms | ALPBRE, BCAN isoform 1, BEHAB, Brevican, CSPG7, LOC100910284 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcan often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Human growth factor-like EGF
- hyaluronan binding domain
- central domain
- G1-domain
- Extracellular link domain
- protein binding
- EGF-like domain
- EGF_CA
- CCP
- core
- Link_Domain
- Immunoglobulin like
- Lectin C-type domain
- Sushi repeat (SCR repeat)
- complement regulatory protein domain
- G3 domain
- Immunoglobulin V-set domain
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic fatigue syndrome
- carcinoma in situ
- epithelial cancer in situ
- proliferative diabetic retinopathy
- glioblastoma cancer
role in cell
- growth
- expression in
- adhesion
- formation
- outgrowth
- activation in
- maturation
- invasion
- stabilization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- Golgi lumen
- glutaminergic synapse
- axon component
- cell surface
- cellular membrane
- synaptic membrane
- lysosomal compartment
- nodes of Ranvier
- axon initial segments
- synapse
- extracellular matrix
- perikaryon
- axons
- dendrites
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcan gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- central nervous system development
- synapse maturation
- positive regulation of neuroblast proliferation
- cell adhesion
- hippocampus development
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- perineuronal net
- synapse
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hyaluronic acid binding
- carbohydrate binding