RAB25 Gene Summary [Human]
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | RAB25 |
| Official Name | RAB25, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:18238] |
| Ensembl ID | ENSG00000132698 |
| Bio databases IDs | |
| Aliases | RAB25, member RAS oncogene family |
| Synonyms | AV012978, CATX-8, RAB11C, RAB25, member RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- AAA domain
- myosin binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- endometriosis
- esophageal atresia
- hyperplasia
role in cell
- proliferation
- expression in
- migration
- formation
- activation in
- reorganization in
- invasion
- morphogenesis
- invasion by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- Plasma Membrane
- recycling endosomes
- cytoplasmic vesicles
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein transport
- epithelial cell morphogenesis
- positive regulation of epithelial cell migration
- regulation of vesicle-mediated transport
- exocytosis
- pseudopodium organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- pseudopodium membrane
- cytoplasmic vesicle
- Golgi apparatus
- recycling endosome
- pseudopodium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- myosin V binding