RGS2 Gene Summary [Human]
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]
Details
| Type | Processed Transcript |
| Official Symbol | RGS2 |
| Official Name | regulator of G protein signaling 2 [Source:HGNC Symbol;Acc:HGNC:9998] |
| Ensembl ID | ENSG00000116741 |
| Bio databases IDs | |
| Aliases | regulator of G protein signaling 2 |
| Synonyms | G0/G1 switch regulatory protein 8, G0S8, GOS8, Regulator of g protein signaling, Regulator of g-protein signaling 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- beta-tubulin binding
- calmodulin binding
- enzyme inhibitor activity
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- enzyme regulator activity
Pathways
Biological processes and signaling networks where the RGS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- breast cancer
- uterine serous papillary cancer
- COVID-19
- bronchoconstriction
- hypertension
- organismal death
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- preeclampsia
- Ullrich congenital muscular dystrophy
role in cell
- survival
- expression in
- activation in
- growth
- proliferation
- phosphorylation in
- development
- size
- differentiation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle contraction
- maternal process involved in female pregnancy
- negative regulation of MAP kinase activity
- G-protein coupled receptor signaling pathway
- negative regulation of cell growth involved in cardiac muscle cell development
- spermatogenesis
- relaxation of vascular smooth muscle
- regulation of G-protein coupled receptor protein signaling pathway
- negative regulation of G-protein coupled receptor protein signaling pathway
- response to ethanol
- negative regulation of phospholipase activity
- brown fat cell differentiation
- response to amphetamine
- negative regulation of cardiac muscle hypertrophy
- positive regulation of neuron projection development
- negative regulation of translation
- regulation of adrenergic receptor signaling pathway
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- nucleolus
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- G-protein alpha-subunit binding
- beta-tubulin binding
- GTPase activity
- GTPase activator activity
- adenylate cyclase inhibitor activity