AGAP3 Gene Summary [Human]
This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
Details
| Type | Processed Transcript |
| Official Symbol | AGAP3 |
| Official Name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [Source:HGNC Symbol;Acc:HGNC:16923] |
| Ensembl ID | ENSG00000133612 |
| Bio databases IDs | |
| Aliases | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 |
| Synonyms | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, AV028425, Centaurin gamma3, CENTG3, cnt-g3, CRAG, Crag., LOC100134082, LOC100503649, MRIP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGAP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- Ankyrin repeats (3 copies)
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Ras subfamily of RAS small GTPases
- Putative GTP-ase activating proteins for the small GTPase, ARF
- PH domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- cell periphery
- PML nuclear bodies
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGAP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell periphery
Molecular Function
What the gene product does at the molecular level
- GTP binding
- metal ion binding
- polyubiquitin binding
- GTPase activity
- GTPase activator activity