MTF2 Gene Summary [Human]
Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm; focal adhesion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MTF2 |
| Official Name | metal response element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:29535] |
| Ensembl ID | ENSG00000143033 |
| Bio databases IDs | |
| Aliases | metal response element binding transcription factor 2, polycomb-like 2, tudor domain containing 19A |
| Synonyms | 9230112N11Rik, C76717, dJ976O13.2, M96, metal response element binding transcription factor 2, PCL2, RGD1304727, TDRD19A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Polycomb-like MTF2 factor 2
- PHD zinc finger
- histone binding
- transcription regulator
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- Tudor domain superfamily
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Parkinson disease
role in cell
- differentiation
- binding in
- repression in
- replicative senescence
- upregulation in
- maintenance
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- stem cell maintenance
- stem cell differentiation
- regulation of gene expression, epigenetic
- segment specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ESC/E(Z) complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- metal ion binding
- methylated histone residue binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- chromatin binding