FST Gene Summary [Human]
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FST |
| Official Name | follistatin [Source:HGNC Symbol;Acc:HGNC:3971] |
| Ensembl ID | ENSG00000134363 |
| Bio databases IDs | |
| Aliases | follistatin |
| Synonyms | AL033346, D2Mgi51, FOL1, follistatin, Follistatin 288, FS, fs315, Fst-288, RATFOL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- receptor antagonist activity
- activin binding
- nuclear localization sequence
- heparin binding domain
- protein binding
- KAZAL_FS
- Follistatin/Osteonectin-like EGF domain
- follistatin (FS) domain
Pathways
Biological processes and signaling networks where the FST gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gout
- migraines
- hyperkeratosis
- hyperplasia
- autosomal dominant polycystic kidney disease
- organismal death
- Dupuytren contracture
- growth failure
- primary biliary cirrhosis
role in cell
- activation in
- blebbing
- proliferation
- formation
- phosphorylation in
- migration
- expression in
- growth
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte proliferation
- multicellular organismal development
- pattern specification process
- gamete generation
- odontogenesis of dentin-containing tooth
- response to organic cyclic compound
- female gonad development
- hemopoietic progenitor cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of epithelial cell differentiation
- skeletal system development
- negative regulation of activin receptor signaling pathway
- BMP signaling pathway
- cell differentiation
- hair follicle morphogenesis
- regulation of BMP signaling pathway
- positive regulation of hair follicle development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- activin receptor antagonist activity
- protein binding
- activin binding
- heparan sulfate proteoglycan binding