KLB Gene Summary [Human]
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KLB |
| Official Name | klotho beta [Source:HGNC Symbol;Acc:HGNC:15527] |
| Ensembl ID | ENSG00000134962 |
| Bio databases IDs | |
| Aliases | klotho beta, b-Klotho |
| Synonyms | AABR07015003.1, beta KLOTHO, BKL, Klb-ps1, klotho beta, klotho β, RGD1308227, β KLOTHO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- fibroblast growth factor binding
- enzyme
- protein binding
- fibroblast growth factor receptor binding
- Glycosyl hydrolase family 1
- beta-galactosidase
- Glycosyl hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- non-insulin-dependent diabetes mellitus
- neoplasia
- alcoholism
- epithelial cancer
- prostate cancer
- hepatocellular carcinoma
- fibrosis
- gout
- weight loss
role in cell
- expression in
- accumulation in
- release
- phosphorylation in
- binding in
- growth
- apoptosis
- proliferation
- accumulation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- fibroblast growth factor binding
- hydrolase activity, hydrolyzing O-glycosyl compounds
- fibroblast growth factor receptor binding