Klb Gene Summary [Mouse]
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in membrane. Is expressed in several structures, including extraembryonic component; gut; liver; lung; and thymus. Orthologous to human KLB (klotho beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klb |
| Official Name | klotho beta [Source:MGI Symbol;Acc:MGI:1932466] |
| Ensembl ID | ENSMUSG00000029195 |
| Bio databases IDs | |
| Aliases | klotho beta |
| Synonyms | AABR07015003.1, beta KLOTHO, BKL, Klb-ps1, klotho beta, klotho β, RGD1308227, β KLOTHO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- fibroblast growth factor binding
- enzyme
- protein binding
- fibroblast growth factor receptor binding
- Glycosyl hydrolase family 1
- beta-galactosidase
- Glycosyl hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- non-insulin-dependent diabetes mellitus
- neoplasia
- alcoholism
- epithelial cancer
- prostate cancer
- hepatocellular carcinoma
- fibrosis
- gout
- weight loss
role in cell
- expression in
- accumulation in
- release
- phosphorylation in
- binding in
- growth
- apoptosis
- proliferation
- accumulation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- fibroblast growth factor binding
- hydrolase activity, hydrolyzing O-glycosyl compounds
- fibroblast growth factor receptor binding