PRR5L Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of mRNA catabolic process; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PRR5L |
| Official Name | proline rich 5 like [Source:HGNC Symbol;Acc:HGNC:25878] |
| Ensembl ID | ENSG00000135362 |
| Bio databases IDs | |
| Aliases | proline rich 5 like, protein observed with Rictor-2 |
| Synonyms | 2600010E01RIK, 4833411O04Rik, FLJ22630, Gm4347, LOC100048399, proline rich 5 like, PROTOR2, RGD1309969 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRR5L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- HbrB-like
- protein binding
Pathways
Biological processes and signaling networks where the PRR5L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- atopic dermatitis
- multiple sclerosis
- alcoholic liver disease
- respiratory disorder
- asthma
- Crohn disease
- oligoarticular juvenile idiopathic arthritis
- eczema
- inflammatory bowel disease
role in cell
- migration by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRR5L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- positive regulation of mRNA catabolic process
- protein kinase B signaling cascade
- negative regulation of signal transduction
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- cellular response to oxidative stress
- positive regulation of protein kinase B signaling cascade
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- TORC2 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding