MAPKAP1 Gene Summary [Human]
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAPKAP1 |
| Official Name | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] |
| Ensembl ID | ENSG00000119487 |
| Bio databases IDs | |
| Aliases | MAPK associated protein 1, stress-activated protein kinase-interacting 1 |
| Synonyms | AI591529, D230039K05Rik, JC310, LOC100912221, MAPK associated protein 1, MIP1, mitogen-activated protein kinase associated protein 1, mSIN1, SIN1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAPKAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- SAPK-interacting protein 1 (Sin1), middle CRIM domain
- protein kinase binding
- Stress-activated map kinase interacting protein 1 (SIN1)
- protein binding activity, bridging
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- phosphatidylinositol binding
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- Ras-binding domain
- SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
Pathways
Biological processes and signaling networks where the MAPKAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- medullary thyroid carcinoma
- papillary thyroid cancer
- immune thrombocytopenia
- papillary thyroid carcinoma
- diverticular disease
- cytopathic effect
- medullary thyroid cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- activation in
- accumulation
- development
- colony formation
- chemotaxis
- reorganization
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- perinuclear region
- Nucleus
- Plasma Membrane
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- mitochondrial outer membrane
- endosomal membrane
- nucleoplasm
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAPKAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular response to oxidative stress
- positive regulation of cell growth
- cellular response to nutrient levels
- negative regulation of Ras protein signal transduction
- cytoskeleton organization
- negative regulation of apoptotic process
- substantia nigra development
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- TORC2 complex
- cytoplasm
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein kinase binding
- protein binding
- small GTPase binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidic acid binding
- phosphatidylinositol-3,4-bisphosphate binding
- binding, bridging