RAB11FIP5 Gene Summary [Human]
Enables gamma-tubulin binding activity. Involved in cellular response to acidic pH; negative regulation of adiponectin secretion; and regulation of protein localization to cell surface. Located in centriolar satellite and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB11FIP5 |
| Official Name | RAB11 family interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:24845] |
| Ensembl ID | ENSG00000135631 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 5 |
| Synonyms | 9130206P09Rik, D6Ertd32e, GAF1, pp75, RAB11 family interacting protein 5, RAB11 family interacting protein 5 (class I), RIP11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11FIP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- Rab11 binding domain
- FIP domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- epithelial uterine cancer
- cervical cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
regulates
- ADIPOQ
- RAB11
role in cell
- long term synaptic depression
- response by
- entrance
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- Plasma Membrane
- basal bodies
- endosomes
- centrosome
- Golgi Apparatus
- Mitochondria
- mitochondrial outer membrane
- endosomal membrane
- nuclear speckles
- recycling endosomes
- early endosomes
- secretory granules
- presynaptic terminals
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11FIP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization at cell surface
- insulin secretion involved in cellular response to glucose stimulus
- negative regulation of adiponectin secretion
- regulated secretory pathway
- cellular response to acidity
Cellular Component
Where in the cell the gene product is active
- secretory granule
- centriolar satellite
- phagocytic vesicle
- Golgi membrane
- Golgi apparatus
- mitochondrial outer membrane
- early endosome membrane
- early endosome
- transport vesicle membrane
- intracellular membrane-bounded organelle
- mitochondrion
- recycling endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- gamma-tubulin binding