RAB11FIP4 Gene Summary [Human]
The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | RAB11FIP4 |
| Official Name | RAB11 family interacting protein 4 [Source:HGNC Symbol;Acc:HGNC:30267] |
| Ensembl ID | ENSG00000131242 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 4 |
| Synonyms | A730072L08RIK, ARFOPHILIN-2, FIP4-Rab11, LOC153077, mKIAA1821, RAB11 family interacting protein 4, RAB11 family interacting protein 4 (class II), RGD1305063 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB11FIP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- Tropomyosin like
- PspA/IM30 family
- FIP domain
- EF-hand domain pair
- enzyme binding
- protein homodimerization
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- acute myeloid leukemia
- metastasis
- liver cancer
- epithelial cancer
- organismal death
- hepatocellular carcinoma
- cancer
- advanced cancer
role in cell
- expression in
- phosphorylation in
- invasion by
- migration
- distribution
- cytokinesis in
- mobility
- invasiveness
- condensation
- dispersal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- pericentrosomal region
- perinuclear region
- cellular membrane
- focal adhesions
- endosomes
- Golgi Apparatus
- midbody
- endosomal membrane
- endocytotic vesicle
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB11FIP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cytokinesis
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- centrosome
- extracellular space
- endosome
- cleavage furrow
- spindle
- midbody
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- calcium ion binding
- small GTPase binding