IMP4 Gene Summary [Human]
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | IMP4 |
| Official Name | IMP U3 small nucleolar ribonucleoprotein 4 [Source:HGNC Symbol;Acc:HGNC:30856] |
| Ensembl ID | ENSG00000136718 |
| Bio databases IDs | |
| Aliases | IMP U3 small nucleolar ribonucleoprotein 4, IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) |
| Synonyms | BXDC4, D1WSU40E, IMP4, U3 small nucleolar ribonucleoprotein, IMP U3 small nucleolar ribonucleoprotein 4, LRRGT00017, RGD1308463 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IMP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Imp4 domain
- coiled-coil domain
- Brix domain
- protein binding
- The Brix domain is found in a number of eukaryotic proteins
- Sigma-70 motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IMP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA
- ribosomal small subunit biogenesis
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- Mpp10 complex
- preribosome
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- snoRNA binding
- protein binding
- rRNA primary transcript binding