TOR1B Gene Summary [Human]
The protein encoded by this gene is an ATPase found primarily in the endoplasmic reticulum and nuclear envelope. This gene has a highly-similar neighboring gene, TOR1A, that encodes a protein that is likely to interact in a complex with this protein. Finally, this protein may act as a chaperone and play a role in maintaining the integrity of the nuclear envelope and endoplasmic reticulum. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | TOR1B |
| Official Name | torsin family 1 member B [Source:HGNC Symbol;Acc:HGNC:11995] |
| Ensembl ID | ENSG00000136816 |
| Bio databases IDs | |
| Aliases | torsin family 1 member B, torsin B |
| Synonyms | 2610016F05Rik, DQ1, TorB, torsinB, torsin family 1 member B, torsin family 1, member B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Torsin
- enzyme
- protein binding
- identical protein binding
- AAA domain (Cdc48 subfamily)
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- systemic sclerosis
- lung cancer
- nonalcoholic fatty liver disease
regulates
role in cell
- morphology
- formation
- blebbing
- organization
- formation in
- blebbing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone mediated protein folding requiring cofactor
- nuclear membrane organization
- endoplasmic reticulum organization
- response to unfolded protein
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum lumen
- nuclear membrane
- extracellular vesicular exosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- kinesin binding