ANGPTL2 Gene Summary [Human]
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ANGPTL2 |
| Official Name | angiopoietin like 2 [Source:HGNC Symbol;Acc:HGNC:490] |
| Ensembl ID | ENSG00000136859 |
| Bio databases IDs | |
| Aliases | angiopoietin like 2 |
| Synonyms | AI593246, AL2, angiopoietin-like 2, ARP2, AW260363, HARP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANGPTL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- receptor binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- cancer
- metastasis
- tumorigenesis
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- obesity
- squamous cell skin cancer
role in cell
- binding in
- expression in
- proliferation
- production in
- aggregation
- cell spreading
- colony formation
- transformation
- degradation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANGPTL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding