Angptl2 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in blood coagulation. Located in extracellular space. Is expressed in several structures, including brain; intraembryonic coelom; limb segment; meninges; and skeleton. Used to study dermatomyositis. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angptl2 |
| Official Name | angiopoietin-like 2 [Source:MGI Symbol;Acc:MGI:1347002] |
| Ensembl ID | ENSMUSG00000004105 |
| Bio databases IDs | |
| Aliases | angiopoietin-like 2 |
| Synonyms | AI593246, AL2, angiopoietin-like 2, ARP2, AW260363, HARP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angptl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- receptor binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- cancer
- metastasis
- tumorigenesis
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- obesity
- squamous cell skin cancer
role in cell
- binding in
- expression in
- proliferation
- production in
- aggregation
- cell spreading
- colony formation
- transformation
- degradation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angptl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding