PPIL1 Gene Summary [Human]
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PPIL1 |
| Official Name | peptidylprolyl isomerase like 1 [Source:HGNC Symbol;Acc:HGNC:9260] |
| Ensembl ID | ENSG00000137168 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase like 1, cyclophilin like 1 |
| Synonyms | 1110060O10Rik, CGI-124, CYCLOPHILIN-RELATED, CYPL1, hCyPX, PCH14, peptidylprolyl isomerase (cyclophilin)-like 1, peptidylprolyl isomerase like 1, Peptidylpropyl Isomerase - Like 1, PPIase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- cyclosporin A binding
- protein domain specific binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pontocerebellar hypoplasia type 14
- congenital pontocerebellar hypoplasia
- neurodevelopmental disorder
- major depression
- overall survival
- idiopathic scoliosis
role in cell
- apoptosis
- growth
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- Nucleus
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein peptidyl-prolyl isomerization
- protein folding
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- U2-type catalytic step 2 spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding