MOG Gene Summary [Human]
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MOG |
| Official Name | myelin oligodendrocyte glycoprotein [Source:HGNC Symbol;Acc:HGNC:7197] |
| Ensembl ID | ENSG00000137345 |
| Bio databases IDs | |
| Aliases | myelin oligodendrocyte glycoprotein |
| Synonyms | B230317G11RIK, BTN6, BTNL11, MOGIG2, MOG IG-2', MYELIN OLIGODENDROCYTE GLYCOPROTEIN, NRCLP7, OLIGODENDROCYTE MYELIN GLYCOPROTEIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- demyelination
- experimental autoimmune encephalomyelitis
- paralysis
- experimental allergic encephalomyelitis (chronic relapsing)
- narcolepsy type 7
- inflammatory bowel disease
- insomnia
- schizophrenia
- delayed hypersensitive reaction
- weight loss
role in cell
- proliferation
- expression in
- activation
- differentiation
- number
- apoptosis
- accumulation in
- quantity
- accumulation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent-insoluble membrane fraction
- myelin enriched fraction
- myelin-derived rafts
- cell surface
- cellular membrane
- Plasma Membrane
- myelin sheath outer loop
- myelin sheath
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- central nervous system development
- cell adhesion
- regulation of cytokine production
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- viral receptor activity
- receptor binding