TRIM31 Gene Summary [Human]
This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Retained Intron |
| Official Symbol | TRIM31 |
| Official Name | tripartite motif containing 31 [Source:HGNC Symbol;Acc:HGNC:16289] |
| Ensembl ID | ENSG00000137397 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 31 |
| Synonyms | BC026666, C6orf13, HCG1, HCGI, RNF, Trim31l, tripartite motif-containing 31 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- RING-H2 zinc finger domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- peritonitis
- dextran sodium sulfate-induced colitis
- chronic obstructive pulmonary disease
- insomnia
- breast cancer
- autoimmune thyroid disease
- insulin-dependent diabetes mellitus
- prostate cancer
- ulcerative colitis
role in cell
- expression in
- migration
- proliferation
- binding in
- K63 polyubiquitination in
- cell viability
- ubiquitination in
- invasion by
- colony formation by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- positive regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of NLRP3 inflammasome complex assembly
- ubiquitin-dependent protein catabolic process
- inflammatory response
- release of virus from host
- negative regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- protein K63-linked ubiquitination
- defense response to virus
- protein ubiquitination
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription coactivator activity