PI15 Gene Summary [Human]
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PI15 |
| Official Name | peptidase inhibitor 15 [Source:HGNC Symbol;Acc:HGNC:8946] |
| Ensembl ID | ENSG00000137558 |
| Bio databases IDs | |
| Aliases | peptidase inhibitor 15 |
| Synonyms | CRISP8, P24TI, P25TI, peptidase inhibitor 15, SugarCrisp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PI15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PI15 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity