PLCB2
PLCB2 Gene Summary
The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Details
| Type | Retained Intron |
| Official Symbol | PLCB2 |
| Official Name | phospholipase C beta 2 [Source:HGNC Symbol;Acc:HGNC:9055] |
| Ensembl ID | ENSG00000137841 |
| Bio databases IDs | |
| Aliases | phospholipase C beta 2 |
| Synonyms | AI550384,B230205M18,B230205M18Rik,B230399N12,phospholipase C beta 2,phospholipase C, beta 2,phospholipase C β 2,phospholipase C, β 2,Phospolipase C β 2,PLC-beta-2,PLC-β-2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- enzyme
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Family with sequence similarity 184, A and B
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- tail domain
- Cell division protein ZapB
- C2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- phospholipid binding
- Domain of unknown function (DUF4515)
- Ezrin/radixin/moesin, alpha-helical domain
- E2 domain of amyloid precursor protein
- phospholipase C
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- PLC-beta C terminal
- phosphoinositide phospholipase C
- binding protein
- MAP7 (E-MAP-115) family
- Phosphoinositide-specific phospholipase C, efhand-like
- PDZ binding motif
- Apolipoprotein A1/A4/E domain
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the PLCB2 gene plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Dendritic Cell Maturation
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- fMLP Signaling in Neutrophils
- Gustation Pathway
- Gαq Signaling
- IL-8 Signaling
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- WDR26
- G protein beta gamma core
- GNAQ
- HNRNPCL2
- TRPM7
- KIF14
- guanosine 5'-O-(3-thiotriphosphate)
- L-alpha-palmitoyloleolyl-phosphatidylcholine
- phosphatidylethanolamine
- 1-palmitoyl-2-oleoylphosphatidylserine
disease
- infection
- hypertension
- diabetic nephropathy
- diabetes mellitus
- schizophrenia
- lung injury
- androgenic alopecia
- coronary artery disease
- chronic kidney disease
- idiopathic scoliosis
regulated by
- tretinoin
- butyric acid
- G beta3 gamma13
- ADRA1B
- tetradecanoylphorbol acetate
- TFAM
- PSMB11
- GPSM3
- G protein alpha i
- G protein beta gamma core
regulates
- NCF1
- adenosine triphosphate
- Ca2+
- superoxide
- phosphatidylinositol 4,5-bisphosphate
- inositol phosphate
- GNB4
- Immunoglobulin
- Integrin alpha L beta 2
- 1,4,5-IP3
role in cell
- proliferation
- activation in
- migration
- mobilization in
- adhesion
- function
- aggregation
- chemotaxis
- transepithelial migration
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- cytosol
- zymogen granules
- axon initial segments
- secretory granules
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PLCB2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- detection of chemical stimulus involved in sensory perception of bitter taste
- phosphatidylinositol metabolic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- release of sequestered calcium ion into cytosol
- phospholipid metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- G-protein beta/gamma-subunit complex
- cytoplasm
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- phospholipase C activity
- calcium ion binding
- G-protein beta/gamma-subunit complex binding
- phospholipid binding