Plcb2 Gene Summary [Mouse]
Predicted to enable G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol-4,5-bisphosphate phospholipase C activity; and phospholipid binding activity. Involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within sensory perception of bitter taste. Located in cytoplasm. Is active in neuronal dense core vesicle. Is expressed in several structures, including early conceptus; genitourinary system; gut; immune system; and liver. Orthologous to human PLCB2 (phospholipase C beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcb2 |
| Official Name | phospholipase C, beta 2 [Source:MGI Symbol;Acc:MGI:107465] |
| Ensembl ID | ENSMUSG00000040061 |
| Bio databases IDs | |
| Aliases | phospholipase C, beta 2 |
| Synonyms | AI550384, B230205M18, B230205M18Rik, B230399N12, phospholipase C beta 2, phospholipase C, beta 2, phospholipase C β 2, phospholipase C, β 2, Phospolipase C β 2, PLC-beta-2, PLC-β-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- enzyme
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Family with sequence similarity 184, A and B
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- tail domain
- Cell division protein ZapB
- C2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- phospholipid binding
- Domain of unknown function (DUF4515)
- Ezrin/radixin/moesin, alpha-helical domain
- E2 domain of amyloid precursor protein
- phospholipase C
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- PLC-beta C terminal
- phosphoinositide phospholipase C
- binding protein
- MAP7 (E-MAP-115) family
- Phosphoinositide-specific phospholipase C, efhand-like
- PDZ binding motif
- Apolipoprotein A1/A4/E domain
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the Plcb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Dendritic Cell Maturation
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- fMLP Signaling in Neutrophils
- Gustation Pathway
- Gαq Signaling
- IL-8 Signaling
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- hypertension
- diabetic nephropathy
- diabetes mellitus
- schizophrenia
- lung injury
- androgenic alopecia
- coronary artery disease
- chronic kidney disease
- idiopathic scoliosis
role in cell
- proliferation
- activation in
- migration
- mobilization in
- adhesion
- function
- aggregation
- chemotaxis
- transepithelial migration
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- cytosol
- zymogen granules
- axon initial segments
- secretory granules
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- detection of chemical stimulus involved in sensory perception of bitter taste
- phosphatidylinositol metabolic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- release of sequestered calcium ion into cytosol
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- G-protein beta/gamma-subunit complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- phospholipase C activity
- calcium ion binding
- G-protein beta/gamma-subunit complex binding
- phospholipid binding