TACC2 Gene Summary [Human]
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TACC2 |
| Official Name | transforming acidic coiled-coil containing protein 2 [Source:HGNC Symbol;Acc:HGNC:11523] |
| Ensembl ID | ENSG00000138162 |
| Bio databases IDs | |
| Aliases | transforming acidic coiled-coil containing protein 2 |
| Synonyms | AZU-1, ECTACC, mKIAA4180, transforming acidic coiled-coil containing protein 2, transforming, acidic coiled-coil containing protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TACC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ligand-dependent nuclear receptor interactor
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Growth-arrest specific micro-tubule binding
- transforming acidic coiled-coil domain
- protein domain specific binding
- zDHHC ankyrin repeat binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- non-insulin-dependent diabetes mellitus
- nasopharyngeal cancer
- nasopharyngeal carcinoma
- breast carcinoma
- epithelial cancer
- ovarian carcinoma
- acute myeloid leukemia
- COVID-19
role in cell
- proliferation
- growth
- cell cycle progression
- morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- centrosome
- microtubules
- cytosol
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TACC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- mitotic spindle organization
- cerebral cortex development
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding