NEWGENE_620180 Gene Summary [Rat]
Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_620180 |
| Official Name | solute carrier family 40 member 1 [Source:RGD Symbol;Acc:11441106] |
| Ensembl ID | ENSRNOG00000003872 |
| Bio databases IDs | |
| Aliases | solute carrier family 40 member 1 |
| Synonyms | Car1, Dusg, FP1, FPN, FPN1, Fpt, HFE4, IREG1, MST079, MSTP079, MTP, MTP1, NEWGENE 620180, Ol5, PCM, SLC11A3, Slc39a1, solute carrier family 40 (iron-regulated transporter), member 1, solute carrier family 40 member 1, Zip1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_620180 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron transporter
- Ferroportin1 (FPN1)
- ubiquitination site
- Major Facilitator Superfamily
- iron ion transporter
- protein binding
- identical protein binding
- polypeptide hormone binding
- transporter
- phosphorylation site
Pathways
Biological processes and signaling networks where the Newgene_620180 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- breast cancer
- breast carcinoma
- high-grade serous ovarian cancer
- breast or ovarian cancer
- urogenital cancer
role in cell
- cell death
- expression in
- cell viability
- apoptosis
- mitochondrial respiration in
- degradation in
- accumulation in
- quantity
- production in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- basolateral cell surfaces
- basolateral membrane
- nucleoplasm
- nodes of Ranvier
- synaptic vesicles
- Schmidt-Lanterman incisures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_620180 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- multicellular organismal iron ion homeostasis
- negative regulation of apoptotic process
- apoptotic process
- lymphocyte homeostasis
- transcription from RNA polymerase II promoter
- establishment of localization in cell
- spleen trabecula formation
- positive regulation of transcription from RNA polymerase II promoter
- iron ion transmembrane transport
- endothelium development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synaptic vesicle
- membrane
- cytosol
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- iron ion transmembrane transporter activity
- metal ion binding
- peptide hormone binding
- ferrous iron transmembrane transporter activity