WARS1 Gene Summary [Human]
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | WARS1 |
| Official Name | tryptophanyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12729] |
| Ensembl ID | ENSG00000140105 |
| Bio databases IDs | |
| Aliases | tryptophanyl-tRNA synthetase 1, tryptophan tRNA ligase 1, cytoplasmic |
| Synonyms | GAMMA-2, HMN9, HMND9, IFI53, IFP53, LOC640248, NEDMSBA, TrpRS, tryptophanyl-tRNA synthetase 1, WARS, WRS, γ-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WARS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tryptophan-tRNA ligase
- tRNA synthetases class I (W and Y)
- protein kinase binding
- kinase inhibitor activity
- S15_NS1_EPRS_RNA-bind
- protein domain specific binding
- enzyme
- protein binding
- WHEP-TRS domain
- tryptophanyl-tRNA synthetase
- WHEP-TRS
- protein homodimerization
- nucleotidyl transferase superfamily
Pathways
Biological processes and signaling networks where the WARS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- small cell lung cancer
- autosomal dominant distal hereditary motor neuronopathy type 9
- sporadic amyotrophic lateral sclerosis
- neurodevelopmental disorder with microcephaly and speech delay with brain abnormalities
- celiac disease
- obsessive-compulsive disorder
- systemic lupus erythematosus
- primary antiphospholipid antibody syndrome
- idiopathic scoliosis
role in cell
- activation in
- proliferation
- migration
- phosphorylation in
- chemotaxis
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- Nucleus
- cytosol
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WARS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- positive regulation of gene expression
- negative regulation of cell proliferation
- regulation of angiogenesis
- tryptophanyl-tRNA aminoacylation
- negative regulation of protein kinase activity
- positive regulation of protein complex assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein domain specific binding
- protein homodimerization activity
- protein binding
- kinase inhibitor activity
- tryptophan-tRNA ligase activity