Wars Gene Summary [Mouse]
Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wars |
| Official Name | tryptophanyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:104630] |
| Ensembl ID | ENSMUSG00000021266 |
| Bio databases IDs | |
| Aliases | tryptophanyl-tRNA synthetase |
| Synonyms | GAMMA-2, HMN9, HMND9, IFI53, IFP53, LOC640248, NEDMSBA, TrpRS, tryptophanyl-tRNA synthetase 1, WARS, WRS, γ-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tryptophan-tRNA ligase
- tRNA synthetases class I (W and Y)
- protein kinase binding
- kinase inhibitor activity
- S15_NS1_EPRS_RNA-bind
- protein domain specific binding
- enzyme
- protein binding
- WHEP-TRS domain
- tryptophanyl-tRNA synthetase
- WHEP-TRS
- protein homodimerization
- nucleotidyl transferase superfamily
Pathways
Biological processes and signaling networks where the Wars gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- small cell lung cancer
- autosomal dominant distal hereditary motor neuronopathy type 9
- sporadic amyotrophic lateral sclerosis
- neurodevelopmental disorder with microcephaly and speech delay with brain abnormalities
- celiac disease
- obsessive-compulsive disorder
- systemic lupus erythematosus
- primary antiphospholipid antibody syndrome
- idiopathic scoliosis
role in cell
- activation in
- proliferation
- migration
- phosphorylation in
- chemotaxis
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- Nucleus
- cytosol
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- positive regulation of gene expression
- negative regulation of cell proliferation
- regulation of angiogenesis
- tryptophanyl-tRNA aminoacylation
- negative regulation of protein kinase activity
- positive regulation of protein complex assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein domain specific binding
- protein homodimerization activity
- protein binding
- kinase inhibitor activity
- tryptophan-tRNA ligase activity