LIME1 Gene Summary [Human]
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Details
| Type | Protein Coding |
| Official Symbol | LIME1 |
| Official Name | Lck interacting transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:26016] |
| Ensembl ID | ENSG00000203896 |
| Bio databases IDs | |
| Aliases | Lck interacting transmembrane adaptor 1 |
| Synonyms | 2810038K19Rik, dJ583P15.4, Lck interacting transmembrane adaptor 1, LIME, RGD1562795 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIME1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lck-interacting transmembrane adapter 1
- protein kinase binding
- cytoplasmic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- Huntington disease
role in cell
- accumulation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- raft fractions
- Plasma Membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIME1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol
- regulation of protein kinase B signaling cascade
- regulation of I-kappaB kinase/NF-kappaB cascade
- adaptive immune response
- T cell receptor signaling pathway
- B cell receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- extracellular space
- B cell receptor complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding