Bnip2 Gene Summary [Mouse]
Acts upstream of or within several processes, including blastocyst development; centrosome cycle; and positive regulation of intracellular signal transduction. Located in centriole and spindle pole centrosome. Is expressed in neocortex. Orthologous to human BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bnip2 |
| Official Name | BCL2/adenovirus E1B interacting protein 2 [Source:MGI Symbol;Acc:MGI:109327] |
| Ensembl ID | ENSMUSG00000011958 |
| Bio databases IDs | |
| Aliases | BCL2/adenovirus E1B interacting protein 2 |
| Synonyms | 5730523P12RIK, BCL2/adenovirus E1B interacting protein 2, BCL2 interacting protein 2, BNIP2beta, NIP2, Nip21, Nip2l |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bnip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
- BCH domain
- Divergent CRAL/TRIO domain
- calcium ion binding
- CRAL/TRIO domain
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- epithelial cancer
- prostatic carcinoma
- prostate cancer
regulates
- NFkB (complex)
- CDC42
role in cell
- differentiation
- activation in
- cell viability
- apoptosis
- cycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- tip of protrusion
- intracellular membrane-bounded organelle
- Nucleus
- centrosome
- centriole
- cytosol
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bnip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- GTPase activator activity