TPPP Gene Summary [Human]
Enables several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with microtubule and microtubule bundle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TPPP |
| Official Name | tubulin polymerization promoting protein [Source:HGNC Symbol;Acc:HGNC:24164] |
| Ensembl ID | ENSG00000171368 |
| Bio databases IDs | |
| Aliases | tubulin polymerization promoting protein, brain specific protein p25 alpha |
| Synonyms | 2900041A09Rik, p24, p25, P25 alpha, P25 α, RGD1310121, TPPP1, TPPP/p25, tubulin polymerization promoting protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPPP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- microtubule binding
- tubulin binding
- p25-alpha
- protein homodimerization
- GTPase
- enzyme
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peptic ulcer disease
- hemorrhoid
- Barrett syndrome
- esophageal carcinoma formation
- nonobstructive azoospermia
- Brugada syndrome
- esophageal adenocarcinoma
- nystagmus
- infection by HIV-1
role in cell
- differentiation
- growth
- formation
- organization
- degeneration
- assembly
- bundling
- aggregation in
- bundling in
- microtubule depolymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- lipofuscin-like dots
- perinuclear region
- Nucleus
- Golgi Apparatus
- Mitochondria
- microtubules
- microtubule bundles
- ER-to-Golgi intermediate compartment
- cytosol
- membrane processes
- mitotic spindle
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPPP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- oligodendrocyte development
- regulation of microtubule cytoskeleton organization
- positive regulation of protein polymerization
- microtubule polymerization
- cell division
- astral microtubule organization
- microtubule bundle formation
- myelin assembly
- microtubule nucleation by microtubule organizing center
- positive regulation of protein complex assembly
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- mitotic spindle
- microtubule organizing center
- cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
- microtubule
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- tubulin binding
- protein homodimerization activity
- protein binding
- GTPase activity
- protein dimerization activity
- microtubule binding