NSMF Gene Summary [Human]
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | NSMF |
| Official Name | NMDA receptor synaptonuclear signaling and neuronal migration factor [Source:HGNC Symbol;Acc:HGNC:29843] |
| Ensembl ID | ENSG00000165802 |
| Bio databases IDs | |
| Aliases | NMDA receptor synaptonuclear signaling and neuronal migration factor |
| Synonyms | HH9, Jac, Jacob, NELF, NMDA receptor synaptonuclear signaling and neuronal migration factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NSMF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- myristoylation sequence
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- susceptibility to hypogonadotropic hypogonadism 9 without anosmia
- hypogonadotropic hypogonadism 9
- major depression
- pituitary stalk interruption syndrome
- susceptibility to Kallmann syndrome type 9
regulates
- beta-estradiol
role in cell
- plasticity
- apoptosis
- quantity
- long-term potentiation
- excitatory postsynaptic potential
- abnormal morphology
- migration by
- morphogenesis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cortical cytoskeleton
- Cytoplasm
- cell surface
- somatodendritic region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- nucleoplasm
- nuclear envelope
- nuclear matrix
- dendritic spines
- neurites
- synapse
- chromatin
- perikaryon
- axons
- dendrites
- postsynaptic density
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NSMF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- cellular response to gonadotropin stimulus
- regulation of neuronal synaptic plasticity
- cellular response to electrical stimulus
- positive regulation of protein dephosphorylation
- regulation of neuron apoptotic process
- regulation of dendrite morphogenesis
- positive regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synapse
- perikaryon
- neuron projection
- plasma membrane
- nucleoplasm
- nuclear envelope
- dendrite
- nucleus
- nuclear membrane
- euchromatin
- cytoplasm
- membrane
- nuclear matrix
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- calcium-dependent protein binding