RAD21L1 Gene Summary [Human]
Predicted to enable chromatin binding activity. Predicted to be involved in mitotic sister chromatid cohesion; replication-born double-strand break repair via sister chromatid exchange; and synaptonemal complex assembly. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Predicted to be located in lateral element. Predicted to be part of nuclear meiotic cohesin complex and nuclear mitotic cohesin complex. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAD21L1 |
| Official Name | RAD21 cohesin complex component like 1 [Source:HGNC Symbol;Acc:HGNC:16271] |
| Ensembl ID | ENSG00000244588 |
| Bio databases IDs | |
| Aliases | RAD21 cohesin complex component like 1 |
| Synonyms | dJ545L17.2, Gm14160, LOC682264, MeiRAD21L, RAD21 cohesin complex component like 1, RAD21L, RAD21-like (S. pombe) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD21L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins
- N terminus of Rad21 / Rec8 like protein
- Conserved region of Rad21 / Rec8 like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- synaptonemal complexes
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD21L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- meiotic cell cycle
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- meiotic cohesin complex
- chromosome
Molecular Function
What the gene product does at the molecular level
- chromatin binding