BCAS3 Gene Summary [Human]
Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus; phagophore assembly site; and transcriptionally active chromatin. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BCAS3 |
| Official Name | BCAS3 microtubule associated cell migration factor [Source:HGNC Symbol;Acc:HGNC:14347] |
| Ensembl ID | ENSG00000141376 |
| Bio databases IDs | |
| Aliases | BCAS3 microtubule associated cell migration factor, Rudhira, phagophore assembly factor 2 |
| Synonyms | 1500019F07Rik, 2610028P08Rik, BCAS3 microtubule associated cell migration factor, BCAS3, microtubule associated cell migration factor, GAOB1, HEMARS, K20D4, MAAB, PHAF2, RGD1560788, rudhira |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCAS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Breast carcinoma amplified sequence 3
- histone binding
- ligand-dependent nuclear receptor interactor
- chromatin binding
- protein binding
- enzyme activator activity
- phosphatidylinositol binding
- histone acetyltransferase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- idiopathic scoliosis
- coronary artery disease
- pervasive developmental disorder
- Alzheimer disease
- open-angle glaucoma
- kidney stones
- Hengel-Maroofian-Schols syndrome
- global developmental delay
- glaucoma
role in cell
- migration
- abnormal morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- chromatin fraction
- intermediate filament cytoskeleton
- Cytoplasm
- cell periphery
- synaptic vesicles
- cytoplasmic microtubule
- cell membrane leading edge
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCAS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- response to estrogen stimulus
- angiogenesis
- positive regulation of catalytic activity
- autophagy
- response to starvation
- cell-cell signaling
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- intermediate filament cytoskeleton
- cell leading edge
- cytoplasm
- pre-autophagosomal structure
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase binding
- ligand-dependent nuclear receptor binding
- protein binding
- histone binding
- beta-tubulin binding
- phosphatidylinositol binding
- acetyltransferase activator activity
- chromatin binding