CBX8 Gene Summary [Human]
Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CBX8 |
| Official Name | chromobox 8 [Source:HGNC Symbol;Acc:HGNC:15962] |
| Ensembl ID | ENSG00000141570 |
| Bio databases IDs | |
| Aliases | chromobox 8, polycomb 3, Pc class 3 homolog (Drosophila) |
| Synonyms | chromobox 8, PC3, RC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CBX8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- CBX family C-terminal motif
- histone binding
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- C-box domain
- protein binding activity, bridging
- protein binding
- enzyme regulator activity
- enzyme activator activity
- single-stranded RNA binding
- Chromo (CHRromatin organization MOdifier) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- breast carcinoma
- brain cancer
- cervical cancer
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- medulloblastoma
regulates
- reporter gene
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- Collagen(s)
- CDKN2A
role in cell
- expression in
- formation
- proliferation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CBX8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of collagen biosynthetic process
- positive regulation of cell proliferation
- cellular response to hydrogen peroxide
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- PRC1 complex
- PcG protein complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin-protein ligase activator activity
- methylated histone residue binding
- single-stranded RNA binding
- chromatin binding