ARHGDIA Gene Summary [Human]
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Processed Transcript |
| Official Symbol | ARHGDIA |
| Official Name | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] |
| Ensembl ID | ENSG00000141522 |
| Bio databases IDs | |
| Aliases | Rho GDP dissociation inhibitor alpha |
| Synonyms | 5330430M07Rik, Bles01, Gdi-1, GDIA1, HEL-S-47e, NPHS8, RhoDGI, RHOGDI, RHOGDI-1, Rho GDI alpha, Rho GDI α, Rho GDP dissociation inhibitor alpha, Rho GDP dissociation inhibitor α, α gdi |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGDIA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- protein kinase binding
- fatty acid binding
- heat shock protein binding
- enzyme binding
- Rho GDP-dissociation inhibitor
- protein binding
- RHO protein GDP dissociation inhibitor
Pathways
Biological processes and signaling networks where the ARHGDIA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulosclerosis
- proteinuria
- pulmonary fibrosis
- hypoplasia
- breast cancer
- nephrotic syndrome type 8
- oligozoospermia
- impaired glucose tolerance
- hypoalbuminemia
- cold thyroid nodule
role in cell
- proliferation
- expression in
- production in
- apoptosis
- migration
- number
- activation in
- abnormal morphology
- function
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cytoskeleton
- Extracellular Space
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- immunological synapses
- cytosol
- growth cone
- synapse
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGDIA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- regulation of protein localization
- negative regulation of apoptotic process
- Rho protein signal transduction
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- extracellular vesicular exosome
- membrane
- cytosol
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- Rho GDP-dissociation inhibitor activity
- GTPase activator activity