Arhgdia Gene Summary [Mouse]
Enables Rho GDP-dissociation inhibitor activity. Involved in regulation of synaptic vesicle cycle and semaphorin-plexin signaling pathway. Acts upstream of or within Rho protein signal transduction and regulation of protein localization. Located in immunological synapse and nucleus. Is active in Schaffer collateral - CA1 synapse. Is expressed in brain; early nephron; and heart. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgdia |
| Official Name | Rho GDP dissociation inhibitor (GDI) alpha [Source:MGI Symbol;Acc:MGI:2178103] |
| Ensembl ID | ENSMUSG00000025132 |
| Bio databases IDs | |
| Aliases | Rho GDP dissociation inhibitor (GDI) alpha |
| Synonyms | 5330430M07Rik, Bles01, Gdi-1, GDIA1, HEL-S-47e, NPHS8, RhoDGI, RHOGDI, RHOGDI-1, Rho GDI alpha, Rho GDI α, Rho GDP dissociation inhibitor alpha, Rho GDP dissociation inhibitor α, α gdi |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgdia often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- protein kinase binding
- fatty acid binding
- heat shock protein binding
- enzyme binding
- Rho GDP-dissociation inhibitor
- protein binding
- RHO protein GDP dissociation inhibitor
Pathways
Biological processes and signaling networks where the Arhgdia gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulosclerosis
- proteinuria
- pulmonary fibrosis
- hypoplasia
- breast cancer
- nephrotic syndrome type 8
- oligozoospermia
- impaired glucose tolerance
- hypoalbuminemia
- cold thyroid nodule
role in cell
- proliferation
- expression in
- production in
- apoptosis
- migration
- number
- activation in
- abnormal morphology
- function
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cytoskeleton
- Extracellular Space
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- immunological synapses
- cytosol
- growth cone
- synapse
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgdia gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- regulation of protein localization
- negative regulation of apoptotic process
- Rho protein signal transduction
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- extracellular vesicular exosome
- membrane
- cytosol
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- Rho GDP-dissociation inhibitor activity
- GTPase activator activity