ANAPC11 Gene Summary [Human]
Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ANAPC11 |
| Official Name | anaphase promoting complex subunit 11 [Source:HGNC Symbol;Acc:HGNC:14452] |
| Ensembl ID | ENSG00000141552 |
| Bio databases IDs | |
| Aliases | anaphase promoting complex subunit 11 |
| Synonyms | 1110011I19Rik, anaphase promoting complex subunit 11, APC11, Apc11p, HSPC214, RGD1561880 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANAPC11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- RING-H2 zinc finger domain
- Anaphase-promoting complex subunit 11 RING-H2 finger
Pathways
Biological processes and signaling networks where the ANAPC11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANAPC11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of meiotic cell cycle
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of mitotic metaphase/anaphase transition
- mitotic cell cycle
- regulation of mitotic cell cycle
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- anaphase-promoting complex
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- ubiquitin-ubiquitin ligase activity