BIRC6 Gene Summary [Human]
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BIRC6 |
| Official Name | baculoviral IAP repeat containing 6 [Source:HGNC Symbol;Acc:HGNC:13516] |
| Ensembl ID | ENSG00000115760 |
| Bio databases IDs | |
| Aliases | baculoviral IAP repeat containing 6, apollon |
| Synonyms | A430032G04Rik, A430040A19Rik, APOLLON, Baculoviral IAP repeat-containing 6, BRUCE, D630005A10Rik, mKIAA1289, Ubiquitin-conjugating enzyme e2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BIRC6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- cysteine protease inhibitor activity
- ubiquitin conjugating enzyme
- Bir domain
- BIR
- ubiquitin-protein transferase activity
- UBCc_UEV
- Ubc binding domain
- enzyme
- protein binding
- Baculoviral IAP repeat-containing protein 6
Pathways
Biological processes and signaling networks where the BIRC6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- salivary duct carcinoma
- salivary duct cancer
- non-insulin-dependent diabetes mellitus
- growth failure
- substance-related disorder
- bleeding
- castration refractory prostate cancer
- refractive error
role in cell
- formation
- growth
- cell viability
- apoptosis
- formation in
- proliferation
- cell cycle progression
- number
- cytokinesis in
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- endosomes
- Golgi Apparatus
- midbody
- microtubule organizing centers
- cytosol
- cytoplasmic face of plasma membrane
- trans Golgi network
- spindle pole
- axons
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BIRC6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- apoptotic process
- regulation of cytokinesis
- negative regulation of extrinsic apoptotic signaling pathway
- protein phosphorylation
- regulation of cell proliferation
- labyrinthine layer development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- centrosome
- endosome
- microtubule organizing center
- membrane
- spindle pole
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- cysteine-type endopeptidase inhibitor activity