SIK1 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]
Details
| Type | Protein Coding |
| Official Symbol | SIK1 |
| Official Name | salt inducible kinase 1 [Source:HGNC Symbol;Acc:HGNC:11142] |
| Ensembl ID | ENSG00000142178 |
| Bio databases IDs | |
| Aliases | salt inducible kinase 1, myocardial SNF1-like kinase |
| Synonyms | DEE30, Hrt-20, MSK, salt-inducible kinase 1, SIK, SIK1B, SNF1LK, Snfk1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- cAMP response element binding protein binding
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- histone deacetylase binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- early infantile epileptic encephalopathy type 30
- neoplasia
- breast cancer
- dermatomyositis
- allergy
- metastasis
- advanced cancer
- peripheral arterial disease
- colorectal cancer
role in cell
- expression in
- migration
- phosphorylation in
- growth
- invasion by
- colony formation
- differentiation
- stabilization
- oxaliplatin resistance
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of CREB transcription factor activity
- anoikis
- negative regulation of gluconeogenesis
- protein autophosphorylation
- protein phosphorylation
- regulation of mitotic cell cycle
- regulation of sodium ion transport
- rhythmic process
- regulation of cell differentiation
- negative regulation of triglyceride biosynthetic process
- entrainment of circadian clock by photoperiod
- regulation of myotube differentiation
- positive regulation of anoikis
- cardiac muscle cell differentiation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- cAMP response element binding protein binding
- protein kinase binding
- ATP binding
- protein binding
- histone deacetylase binding
- protein serine/threonine kinase activity
- 14-3-3 protein binding