GPR161 Gene Summary [Human]
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | GPR161 |
| Official Name | G protein-coupled receptor 161 [Source:HGNC Symbol;Acc:HGNC:23694] |
| Ensembl ID | ENSG00000143147 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 161 |
| Synonyms | Gm208, Gm208Gpr, G protein-coupled receptor 161, G-protein coupled receptor af091890, RE2, RGD1563245, vl |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR161 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR161 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Parkinson disease
- androgenic alopecia
- acute myeloid leukemia
- breast carcinoma
- brain cancer
- central nervous system cancer
- pediatric cancer
- head and neck cancer
- head and neck neoplasia
role in cell
- proliferation
- accumulation in
- migration
- signaling in
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- cilia
- cellular membrane
- neurites
- glial cell projections
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR161 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cilium
- recycling endosome
- cilium membrane
- neuron projection
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding