GPR35 Gene Summary [Human]
Enables C-X-C chemokine receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR35 |
| Official Name | G protein-coupled receptor 35 [Source:HGNC Symbol;Acc:HGNC:4492] |
| Ensembl ID | ENSG00000178623 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 35 |
| Synonyms | G protein-coupled receptor 35, KPG 007 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-X-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR35 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary sclerosing cholangitis
- gastric carcinoma
- brachydactyly mental retardation syndrome
- inflammatory bowel disease
- Crohn disease
- ulcerative colitis
- gastric epithelial cancer
- ankylosing spondylitis
- bipolar I disorder
role in cell
- colony formation by
- expression in
- migration
- interaction in
- organization
- tubulation by
- proliferation by
- elevation in
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- cytoskeleton organization
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- C-X-C chemokine receptor activity