GATAD2B Gene Summary [Human]
This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | GATAD2B |
| Official Name | GATA zinc finger domain containing 2B [Source:HGNC Symbol;Acc:HGNC:30778] |
| Ensembl ID | ENSG00000143614 |
| Bio databases IDs | |
| Aliases | GATA zinc finger domain containing 2B, transcription repressor p66 beta component of the MeCP1 complex |
| Synonyms | C430014D17Rik, GANDS, GATA zinc finger domain containing 2B, KIAA1150, mKIAA1150, MRD18, p66, P66beta, p68, RGD1308533 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GATAD2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Coiled-coil and interaction region of P66A and P66B with MBD2
- protein binding
- ZnF_GATA
Pathways
Biological processes and signaling networks where the GATAD2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- epithelial cancer
- autosomal dominant mental retardation type 18
- hereditary disorder
- mental retardation
- pervasive developmental disorder
- conduct disorder
- prostatic carcinoma
- male pattern hair loss
role in cell
- expression in
- migration
- quantity
- remodeling
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GATAD2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of cell fate specification
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear speck
- NuRD complex
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- nucleosomal DNA binding
- sequence-specific DNA binding