ITPKB Gene Summary [Human]
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ITPKB |
| Official Name | inositol-trisphosphate 3-kinase B [Source:HGNC Symbol;Acc:HGNC:6179] |
| Ensembl ID | ENSG00000143772 |
| Bio databases IDs | |
| Aliases | inositol-trisphosphate 3-kinase B |
| Synonyms | 1110033J02RIK, Aw121826, E130307H12RIK, inositol 1,4,5-trisphosphate 3-kinase B, inositol-trisphosphate 3-kinase B, IP3-3KB, IP3 3-kinase B, IP3K, IP3K-B, PIG37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITPKB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-trisphosphate 3-kinase
- Inositol polyphosphate kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- Huntington disease
- diarrhea
- Parkinson disease
- allergy
- asthma
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- preeclampsia
role in cell
- number
- proliferation
- phosphorylation in
- differentiation
- survival
- quantity
- accumulation in
- development
- activation
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITPKB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neutrophil apoptotic process
- negative regulation of myeloid cell differentiation
- signal transduction
- phosphatidylinositol phosphorylation
- positive regulation of Ras protein signal transduction
- cell surface receptor signaling pathway
- myeloid cell homeostasis
- positive thymic T cell selection
- positive regulation of alpha-beta T cell differentiation
- inositol trisphosphate metabolic process
- MAPK cascade
- inositol phosphate biosynthetic process
- cellular response to calcium ion
- regulation of protein phosphorylation
- common myeloid progenitor cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- inositol tetrakisphosphate kinase activity