TAOK1 Gene Summary [Human]
Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of JNK cascade. Located in microtubule cytoskeleton and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TAOK1 |
| Official Name | TAO kinase 1 [Source:HGNC Symbol;Acc:HGNC:29259] |
| Ensembl ID | ENSG00000160551 |
| Bio databases IDs | |
| Aliases | TAO kinase 1, prostate-derived sterile 20-like kinase 2, MARK kinase, thousand and one amino acid protein kinase 1 |
| Synonyms | 2810468K05RIK, AU020252, D130018F14RIK, DDIB, hKFC-B, hTAOK1, KFC-B, LOC100506461, LOC100507968, MAP3K16, MARKK, MGC29021, PSK-2, TAO1, TAO kinase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAOK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- protein serine/threonine kinase
- polo kinase kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- myosin binding
- kinase domain
- Protein Kinases, catalytic domain
- alpha-tubulin binding
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast cancer
- neoplasia
- glioblastoma cancer
- hereditary disorder
- colorectal cancer
- developmental delay with intellectual impairment and behavioral abnormalities
- developmental delay without intellectual impairment or behavioral abnormalities
- neurodevelopmental disorder
- developmental delay with or without intellectual impairment or behavioral abnormalities
role in cell
- proliferation
- apoptosis
- survival
- formation
- degradation in
- phosphorylation in
- formation in
- cell rounding
- contraction
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- perinuclear region
- Plasma Membrane
- cytosol
- nuclear bodies
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAOK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- regulation of microtubule cytoskeleton organization
- negative regulation of microtubule depolymerization
- protein autophosphorylation
- microtubule cytoskeleton organization
- central nervous system neuron development
- response to DNA damage stimulus
- protein phosphorylation
- execution phase of apoptosis
- neuron homeostasis
- regulation of actin cytoskeleton organization
- positive regulation of JNK cascade
- regulation of cytoskeleton organization
- phosphorylation
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein serine/threonine kinase activator activity
- protein binding
- beta-tubulin binding
- tau protein binding
- protein kinase activity
- alpha-tubulin binding
- protein serine/threonine kinase activity
- transferase activity
- kinase activity